Content

Bioreactor Modelling and Simulation

  • Mass and energy balances
  • Kinetics & stoichiometry
  • Batch, fed-batch & continuous operation
  • Heat and mass transfer
  • Scale-up & scale-down

Cell Modelling & Simulation

  • Metabolic network reconstruction
  • 13C metabolic flux analysis
  • Stoichiometric and contraint-based modelling
  • Elementary flux mode analysis
  • Flux balance analysis
  • Dynamic network models
  • Prokaryotic & eukaryotic systems

Model-Based Design of Cells & Bioreactors

  • Prediction of optimum yields & pathways
  • Multi-omics driven strain engineering
  • Design Principles of Metabolic Networks
  • Techniques of computational strain design
  • Cell and bioreactor models
  • Experimental design strategies
  • Bioprocess design

Industrial Case Studies

  • Mammalian cells for high-value therapeutics
  • Microbial recombinant protein production
  • Bio-based chemicals and materials
  • High-cell density production
  • Processing renewable raw materials
  • Whole cell biocatalysis

Exercises and Workshops

  • Computer aided exercises
  • Berkeley Madonna & MATLAB software
  • CellNetAnalyzer
  • Supporting computational tools
  • Workshops on selected topics