Bioreactor Modelling and Simulation
- Mass and energy balances
- Kinetics & stoichiometry
- Batch, fed-batch & continuous operation
- Heat and mass transfer
- Scale-up & scale-down
Cell Modelling & Simulation
- Metabolic network reconstruction
- 13C metabolic flux analysis
- Stoichiometric and contraint-based modelling
- Elementary flux mode analysis
- Flux balance analysis
- Dynamic network models
- Prokaryotic & eukaryotic systems
Model-Based Design of Cells & Bioreactors
- Prediction of optimum yields & pathways
- Multi-omics driven strain engineering
- Design Principles of Metabolic Networks
- Techniques of computational strain design
- Cell and bioreactor models
- Experimental design strategies
- Bioprocess design
Industrial Case Studies
- Mammalian cells for high-value therapeutics
- Microbial recombinant protein production
- Bio-based chemicals and materials
- High-cell density production
- Processing renewable raw materials
- Whole cell biocatalysis
Exercises and Workshops
- Computer aided exercises
- Berkeley Madonna & MATLAB software
- CellNetAnalyzer
- Supporting computational tools
- Workshops on selected topics
